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Interactions of dietary whole grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.
Genes may influence the plasma insulin-reducing activity of whole grains in persons of European descent.
This research work examined the correlation between whole grain consumption and genetic variation and plasma levels of fasting glucose and insulin in persons of European descent. Researchers analyzed data obtained from 14 cohort studies encompassing approximately 48,000 subjects of European descents. The plasma concentrations of fasting glucose and insulin were assessed in all the subjects, as well as the presence of the insulin-raising gene GCKR.
Researchers observed low serum concentrations of fasting glucose and insulin in subjects who consumed diets rich in whole grains regularly. However, fasting insulin levels were found to be slightly reduced in habitual consumers of whole grains who possess the insulin-raising gene GCKR. The findings of this analysis support the hypothesis that genes, such as GCKR, may play a significant role in the association between whole grain and plasma fasting glucose and insulin levels in individuals of European descent.
Research Summary Information
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2010
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Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert MF, Ngwa J, van Rooij FJ, Sonestedt E, Wojczynski MK, Ye Z, Tanaka T, Garcia M, Anderson JS, Follis JL, Djousse L, Mukamal K, Papoutsakis C, Mozaffarian D, Zillikens MC, Bandinelli S, Bennett AJ, Borecki IB, Feitosa MF, Ferrucci L, Forouhi NG, Groves CJ, Hallmans G, Harris T, Hofman A, Houston DK, Hu FB, Johansson I, Kritchevsky SB, Langenberg C, Launer L, Liu Y, Loos RJ, Nalls M, Orho-Melander M, Renstrom F, Rice K, Riserus U, Rolandsson O, Rotter JI, Saylor G, Sijbrands EJ, Sjogren P, Smith A, Steingrímsdóttir L, Uitterlinden AG, Wareham NJ, Prokopenko I, Pankow JS, van Duijn CM, Florez JC, Witteman JC; MAGIC Investigators, Dupuis J, Dedoussis GV, Ordovas JM, Ingelsson E, Cupples L, Siscovick DS, Franks PW, Meigs JB.
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Dupuis J, Claudia L, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Lindgren CM, Mägi R, Morris AP, Randal J, Rybin D, Johnson T, Henneman P, Gieger C, Thorleifsson G, Steinthorsdottir V, Dehghan A, Hottenga JJ, Franklin CS, Navarro P, Song K, Goe A, Perry JR, Lajunen T, Grallert H, Li M, Stringham HM, Kumari M, Timpson NJ, Shrader P, Ingelsson E, Zabena C, O'Connell J, Cavalcanti-Proença C, Luan J, Elliott A, McCarroll SA, Payne F, Roccasecca RM, Sethupathy P, Andrew T, Ariyurek Y, Balkau B, Barter P, Bennett AJ, Ben-Shlomo Y, Bergmann S, Bochud M, Boerwinkle E, Bonnefond A, Bonnycastle LL, Böttcher Y, Brunner E, Bumpstead SJ, Chen YD, Chines P, Clarke R, Coin LJ, Crawford GJ, Crisponi L, Day IN, Geus Ed, Dina C, Doney A, Egan JM, Elliott P, Erdos MR, Fischer-Rosinsky A, Forouhi NG, Fox CS, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Groves CJ, Grundy S, Gwilliam R, Hallmans G, Hammond N, Han X, Hartikainen AL, Hayward C, Heath SC, Hercberg S, Herder C, Hicks AA, Hingorani AD, Hofman A, Isomaa B, Jula A, Kaakinen M, Kanoni S, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Lathrop GM, Lawlor DA, Li Y, Lyssenko V, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Morken MA, Naitza S, Narisu N, Neville MJ, Oostra BA, Orrù M, Pakyz R, Palmer CN, Paolisso G, Pattaro C, Pearson D, Peden JF, Perola M, Pfeiffer AF, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Psaty BM, Rathmann W, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Rolandsson O, Sandhu M, Sanna S, Sayer AA, Scheet P, Scott LJ, Seedorf U, Sharp SJ, Shields B, Sijbrands EJ, Silveira A, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen AC, Tanaka T, Tönjes A, Tuomi T, Uitterlinden AG, van Dijk KW, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Watkins H, Weedon MN, Wild SH, Willemsen G, Witteman JC, Yarnell JW, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, GIANT Consortium, Global BPgen Consortium, Loos RJ, Meneton P, Nathan DM, Williams GH, Hattersley AT, Silander K, Salomaa V, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Dedoussis GV, Serrano-Ríos M, Morris AD, Lind L, Franks PW, Ebrahim S, Marmot M, Kuusisto J, Laakso M, Kao WH, Pankow JS, Pramstaller PP, Wichmann HE, Illig T, Rudan I, Wright A, Stumvoll M, Campbell H, Wilson JF, Hamsten A, Bergman RN, Buchanan TA, Collins FS, Mohlke KL, Tuomilehto J, Valle TT, Altshuler D, Rotter JI, Siscovick DS, Penninx BW, Boomsma D, Deloukas P, Spector TD, Frayling TM, Ferrucci L, Kong A, Thorsteinsdottir U, Stefansson K, van Duijn CM, Aulchenko YS, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin MR, Waterworth DM, Vollenweider P, Peltonen L, Mooser V, Abecasis GR, Wareham NJ, Sladek R, Froguel P, Watanabe RM, Meigs JB, Groop L, Boehnke M, McCarthy MI, Florez JC, Barroso I.
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