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Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis
The odds of developing esophageal, head, and neck cancer may be stacked against lovers of ultra-processed foods.
This study looked at the incidence of esophageal, head, and neck cancer based on the level of consumption of ultra-processed foods. Researchers compared the rate of occurrence of cancer of the esophagus, head, and neck among consumers and non-consumers of ultra-processed foods in a study population comprising of nearly half a million men and women.
Researchers observed that esophageal, head, and neck cancer tend to occur more in consumers than among non-consumers of ultra-processed foods. Based on the data from this study, it can be concluded that increased intake of ultra-processed foods may up an individual's chances of coming down with head, neck, and esophageal cancer.
Research Summary Information
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2023
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Fernanda Morales-Berstein, Carine Biessy, Vivian Viallon, Ana Goncalves-Soares, Corinne Casagrande, Bertrand Hémon, Nathalie Kliemann, Manon Cairat, Jessica Blanco Lopez, Aline Al Nahas, Kiara Chang, Eszter Vamos, Fernanda Rauber, Renata Bertazzi Levy, Diana Barbosa Cunha, Paula Jakszyn, Pietro Ferrari, Paolo Vineis, Giovanna Masala, Alberto Catalano, Emily Sonestedt, Yan Borné, Verena Katzke, Rashmita Bajracharya, Claudia Agnoli, Marcela Guevara, Alicia Heath, Loredana Radoï , Francesca Mancini, Elisabete Weiderpass, José María Huerta, María-José Sánchez, Anne Tjønneland, Cecilie Kyrø, Matthias B Schulze, Guri Skeie, Marko Lukic, Tonje Braaten, Marc Gunter , Christopher Millett , Antonio Agudo, Paul Brennan, M Carolina Borges , Rebecca C Richmond, Tom G Richardson, George Davey Smith, Caroline L Relton, Inge Huybrechts; EPIC Network
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MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. dy20206@bristol.ac.uk. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. dy20206@bristol.ac.uk. Nutrition and Metabolism Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Cancer Research Center of Santa Catarina, CEPON, Florianópolis, Brazil. Paris-Saclay University, UVSQ, Inserm "Exposome, Heredity, Cancer and Health" Team, CESP U1018, Gustave Roussy, Villejuif, France. Public Health Policy Evaluation Unit, School of Public Health, Imperial College London, London, UK. Preventive Medicine Department of the Medical School, University of São Paulo, São Paulo, Brazil. Center for Epidemiological Research in Nutrition and Health, University of São Paulo, São Paulo, Brazil. Hésio Cordeiro Institute of Social Medicine, Department of Epidemiology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil. Unit of Nutrition and Cancer, Catalan Institute of Oncology-ICO, L'Hospitalet de Llobregat, Spain. Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Spain. Blanquerna Faculty of Health Sciences, Ramon Llull University, Barcelona, Spain. MRC Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London, W2 1PG, UK. Italian Institute of Technology, Genoa, Italy. Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. Centre for Biostatistics, Epidemiology, and Public Health, Department of Clinical and Biological Sciences, University of Turin, 10043, Orbassano, TO, Italy. Nutrition Epidemiology, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden. Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Instituto de Salud Pública y Laboral de Navarra, 31003, Pamplona, Spain. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain. Navarra Institute for Health Research (IdiSNA), 31008, Pamplona, Spain. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. International Agency for Research on Cancer, World Health Organization, Lyon, France. Department of Epidemiology, Murcia Regional Health Council-IMIB, Murcia, Spain. Escuela Andaluza de Salud Pública (EASP), 18011, Granada, Spain. Instituto de Investigación Biosanitaria ibs.GRANADA, 18012, Granada, Spain. Department of Preventive Medicine and Public Health, University of Granada, 18071, Granada, Spain. Danish Cancer Society Research Center, Diet, Cancer and Health, Strandboulevarden 49, DK-2100, Copenhagen, Denmark. Department of Public Health, University of Copenhagen, DK-2200, Copenhagen, Denmark. Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany. Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway. NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, NOVA University Lisbon, Lisbon, Portugal. Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.
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